Microsatellite
Instability (MSI) Analysis
The MSI Application in GeneMarker®
software, a biologist friendly alternative
to GeneMapper®,
Genotyper™, GeneScan®,
MegaBACE
Genetic Profiler, CEQ™
Fragment Analysis Software; is
directly linked to the main analysis
screen and is an excellent tool for
analysis from kits such as the Promega
MSI Analysis System, Roche
HNPCC Microsatellite Instability Test,
Applied
Biosystems MSI Primers separated
with ABI
PRISM® 310, 3100, 3130, 3500,
3730, Beckman
CEQ™ or MegaBACE™
genetic analyzers for comparison of
tumor to the corresponding normal
sample, as with colorectal,
breast
elevated- microsatelliteinstability-at-selected-tetranucleotide-repeats
(EMAST),
bladder
cancer. This instability is due
to either insertion or deletion of
repeating units during DNA replication
and failure of the mismatch repair
system (MMR) to correct these errors.
GeneMarker software's MSI Analysis
module compares tumor to normal samples
based on peak-to-peak comparison.
The customized final report includes
a header for electronic signature,
trace overlay (tumor and normal),
trace comparison histogram and gain/loss
table.
Trademarks property
of their respective owners
Research use only (RUO)
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