The Pathogenicity Changes pane displays the history of the changes that have been made to the pathogenicity for the variant in reverse chronological order. When a variant is first added to the Geneticist Assistant database, the Pathogenicity is set to Unassigned and the Pathogenicity Status does not have a value. If the Pathogenicity is changed to Deleterious, and the Status is set to Confirmed, for example, then this change and the name of the user who made the change, and the date and the time of the change are recorded and displayed in this pane. For a description of the context menu options for the pane, see Variant information panes.