To configure Geneticist Assistant directories
Before you run Geneticist Assistant for the first time, if you have yet to create your client reference directory, which is the directory contains the information for the reference that are used for aligning the data and/or detecting variants, then you must do so. References are stored in their own folders in this directory. If you have yet to configure the server reference directory, which is the directory on the database server that is to host the reference files, then you must also specify this directory location. Optionally, if you have already configured the client reference directory, but you have not yet submitted data to the Geneticist Assistant database, then you can change the location of the reference directory. Optionally, you can also change the location of the server reference directory and/or specify a report directory.
1. On the Geneticist Assistant main menu, click File > Settings.
The Settings dialog box opens. The General tab is the open tab.
2. Optionally, in the Directories (top) pane, do any or all of the following as appropriate:
• To specify the location of the client reference directory, or change the location of the directory, next to the Reference Directory field, click the Browse button 
, and then browse to and select the appropriate directory.
, and then browse to and select the appropriate directory. | Although not required, SoftGenetics recommends that you create the reference directory on the same computer and drive on which you installed the Geneticist Assistant client. |
 | If you have previously specified the location for the client reference directory and submitted data to the Geneticist Assistant database, then you cannot change its location. |
• To specify the directory in which all Geneticist Assistant reports are to be saved, next to the Report Directory field, click the Browse button , and then browse to and select the directory.
, and then browse to and select the directory.• If your organization also has NextGENe installed, then to use the interactive functionality that is available for Geneticist Assistant and NextGENe, Geneticist Assistant must be able to locate your NextGENe installation. If your Geneticist Assistant instance is installed on the same client as your NextGENe instance, then leave Locate on Startup selected; otherwise, clear Locate on Startup, and then next to the NextGENe Directory field, click the Browse button , and then browse to and select the appropriate directory.
, and then browse to and select the appropriate directory.• To specify the location of the server reference directory, or change the location of the current directory, in the Server Reference Directory field, enter the full path to the appropriate directory, and then click Set.
 | No message opens after you click Set. Also, if you inadvertently clear the path to the server reference directory, then you can click the Refresh icon to immediately repopulate the Server Reference Directory field with the full path and directory name. |
3. If you are done specifying your settings, then click OK to close the Settings dialog box and return to the Geneticist Assistant main window; otherwise, continue to add and/or edit the information on any this tab or any of the other tabs as appropriate.