After you generate an mtDNA project for the first time, the project settings (filter settings and table settings) are saved as Initial_Report at the Project Folder level. After you make any changes to the project settings and/or any manual edits to the project (for example, adding or deleting a variant), you can save these changes as another project report. Each report that you save is saved in a separate sub-folder under the primary project folder with a Change Log file that details the changes made to the project settings and project results. With a project opened in the Mito Alignment viewer, you can load any report that has been saved for the project to immediately update the information that is displayed for the project in the viewer. See: